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Genital Herpes

Evidence‑based, discreet, and effective – manage outbreaks and reduce transmission with aciclovir or valaciclovir.

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Medically authored & reviewed by Dr Abdishakur M Ali General Practitioner and Medical Director
GMC no. 7041056
Last reviewed: May 2026 GPhC Reg. Pharmacy #9011198
✓ GPhC-registered pharmacy #9011198 ✓ Pharmacist independent prescribers ✓ Discreet next-day delivery ✓ UK-regulated

Genital Herpes UK: Complete Guide to Symptoms, Treatment & Suppression

Key fact: Genital herpes is extremely common, manageable, and does not define your health or relationships. Effective antiviral treatment can shorten outbreaks, suppress recurrences, and reduce transmission by up to 50%.

~1 in 10
Adults in the UK carry HSV‑2 (the virus most often causing genital herpes)
70%
Of transmissions occur during asymptomatic shedding – when no sores are visible
50%
Reduction in transmission risk with daily suppressive valaciclovir (BASHH evidence)

What is genital herpes?

Genital herpes is a common sexually transmitted infection (STI) caused by the herpes simplex virus (HSV). Two types exist: HSV‑1 (traditionally cold sores) and HSV‑2 (traditionally genital). Both can cause genital lesions.

Once acquired, the virus travels to a cluster of nerve cells (ganglion) near the spine and remains there for life. It can reactivate periodically, causing outbreaks. There is no cure – but effective antiviral medicines (aciclovir, valaciclovir/Valtrex) control symptoms, speed healing, and lower the chance of passing the virus to partners.

How common is genital herpes in the UK?

Genital herpes is one of the most frequent viral STIs. According to UK Health Security Agency data, around 400,000 people in England are diagnosed each year with a first episode. However, many more carry the virus without ever knowing it – because symptoms can be mild or absent. Estimates suggest 1 in 10 sexually active adults in the UK has HSV‑2, and up to 1 in 3 have HSV‑1 (which can also cause genital herpes through oral sex).

Causes and transmission

Genital herpes is spread through skin‑to‑skin contact, usually during vaginal, anal, or oral sex. The virus is most infectious when sores are present, but asymptomatic shedding – when the virus is on the skin without visible lesions – accounts for up to 70% of transmissions. Condoms reduce but do not eliminate risk, because the virus can be present on skin not covered by a condom.

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HSV‑1

Usually causes cold sores, but increasingly causes genital herpes via oral sex. Tends to recur less often in the genital area.

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HSV‑2

The classic genital herpes virus. More likely to cause frequent recurrences. Around 1 in 10 UK adults carries it.

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Asymptomatic shedding

The virus can be present on the skin without any sores. This is why transmission happens even when you feel completely fine.

Reactivation triggers

Common triggers: stress, illness, tiredness, menstruation, friction, or immunosuppression. Avoiding triggers reduces recurrences.

Symptoms of genital herpes

Many people have no symptoms or very mild ones. When symptoms occur, they usually appear 2–12 days after exposure:

  • Prodrome (warning signs) – tingling, itching, burning, or aching in the genital area 12–24 hours before blisters appear.
  • Painful blisters or ulcers – small red bumps or white blisters that rupture into shallow, painful sores.
  • Flu‑like symptoms – fever, headache, muscle aches, and swollen lymph nodes in the groin (common in first episode).
  • Pain on urination – especially when urine passes over open sores.

First episodes are usually the most severe, lasting 2–4 weeks without treatment. Recurrences are typically milder and shorter – often just a few days of tingling and a small patch of irritation.

When to seek urgent care: If you have difficulty passing urine, cannot walk because of pain, or have a very high fever with a first outbreak, attend a sexual health clinic or A&E.

Diagnosis and when to test

Genital herpes is usually diagnosed clinically – by looking at the lesions. If there is doubt, a swab from a blister or ulcer can be sent for PCR testing to confirm HSV and type (1 vs 2). Blood tests for antibodies are not routinely recommended because they cannot tell you where the infection is (oral vs genital) and a positive result does not prove the current symptoms are herpes.

You should test if: you have typical sores; a partner has been diagnosed; you have recurrent unexplained genital irritation; or you are pregnant with a history of herpes (to plan management at delivery).

1

Clinical assessment

A GP or sexual health clinician examines the area. Often no swab is needed if the appearance is classic.

2

Swab test (if uncertain)

A painless swab of a blister or ulcer is sent for PCR. Results in 3–7 days.

3

Treatment decision

If confirmed, antivirals are prescribed – either for the current outbreak (episodic) or daily to prevent recurrences (suppressive).

Treatment options: aciclovir and valaciclovir (Valtrex)

Both aciclovir and valaciclovir (brand name Valtrex) are highly effective antiviral medicines. They do not cure herpes but stop the virus from multiplying, giving your immune system the upper hand.

FeatureAciclovirValaciclovir (Valtrex)
How it worksDirect antiviral – requires more frequent dosingProdrug – converts to aciclovir in the body, giving higher levels
Episodic dosing200mg five times daily or 400mg three times daily for 5 days500mg twice daily for 3 days (or 2g twice daily for 1 day for some patients)
Suppressive dosing400mg twice daily500mg once daily (or 250mg twice daily)
ConvenienceLess convenient – multiple doses per dayMore convenient – once or twice daily
CostLower (£17.99 per pack at Access Doctor)Higher (£34.99 per pack)

Episodic vs suppressive therapy – which is right for you?

Episodic treatment means taking antivirals only when you feel an outbreak coming on (prodrome) or as soon as blisters appear. It shortens the outbreak by 2–3 days and reduces severity. Ideal for people with infrequent recurrences (less than 6 per year).

Suppressive treatment means taking a lower daily dose every day, whether or not you have symptoms. It reduces recurrences by 70–80% and lowers transmission risk to partners by about 50% (proven for valaciclovir). Ideal for people with frequent recurrences (≥6/year), severe outbreaks, or a partner without herpes.

Clinical tip: Many people start with episodic treatment and later switch to suppressive if recurrences become bothersome. Suppressive therapy is reviewed every 6–12 months and can be stopped for a trial period – herpes does not become resistant to antivirals with standard use.

Preventing transmission to partners

  • Daily suppressive therapy – reduces asymptomatic shedding and transmission by ~50% (valaciclovir 500mg once daily).
  • Condom use – reduces risk by about 30‑50%, but does not cover all skin.
  • Avoid sex during prodrome or visible sores – the highest risk period.
  • Disclosure – being open with partners allows informed decisions and often strengthens relationships.

Overcoming stigma – why online treatment helps

Genital herpes carries an unjustified stigma, despite being an ordinary, manageable skin condition. Many people avoid seeking help because of embarrassment – but online consultation services like Access Doctor are designed specifically for this. You complete a short medical questionnaire from your phone or computer, and a GPhC‑registered pharmacist independent prescriber reviews it. If treatment is suitable, your aciclovir or Valtrex is dispatched in plain, discreet packaging for next‑day delivery. No need to visit a GP surgery or sexual health clinic in person unless complications arise.

Remember: Herpes does not affect your worth. It does not cause long‑term health problems for most people. Effective treatment gives you control.

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Frequently Asked Questions about genital herpes

Can genital herpes be cured?

No, there is no cure. The virus stays in nerve cells for life. However, antiviral medicines (aciclovir, valaciclovir) control outbreaks so effectively that many people have few or no symptoms.

How quickly does aciclovir or Valtrex work?

If started within 24‑48 hours of first tingling, treatment can shorten an outbreak by 2‑3 days. Many people feel improvement within 24 hours.

What is the difference between aciclovir and valaciclovir (Valtrex)?

Valaciclovir is a prodrug that converts to aciclovir in the body, giving higher blood levels with fewer daily doses – twice daily vs three to five times for aciclovir. Both are equally effective; Valtrex is more convenient but more expensive.

Do I need a prescription for herpes treatment in the UK?

Yes – aciclovir and valaciclovir are prescription‑only. Access Doctor provides an online consultation with a GPhC‑registered prescriber. If suitable, a prescription is issued and dispensed.

Will suppressive therapy stop me passing herpes to my partner?

It reduces transmission risk by about 50% (valaciclovir 500mg daily), but does not eliminate it. Combined with condoms and avoiding sex during outbreaks, risk is very low.

Can I get Valtrex (valaciclovir) online?

Yes – Access Doctor offers both generic valaciclovir and branded Valtrex after a consultation. Choose whichever suits your budget and convenience.

References

  1. NICE. Genital herpes – management. Clinical Knowledge Summaries. cks.nice.org.uk/genital-herpes
  2. British Association for Sexual Health and HIV (BASHH). UK national guideline for the management of genital herpes. 2024. bashh.org/guidelines
  3. UK Health Security Agency. Genital herpes data tables. 2025.
  4. Corey L, Wald A, et al. Once‑daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004;350(1):11–20. pubmed.ncbi.nlm.nih.gov/14702423
  5. Electronic Medicines Compendium. Aciclovir 400mg tablets – SmPC. Valtrex 500mg tablets – SmPC. medicines.org.uk/emc

Medical disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment. Antiviral medicines are prescription‑only – a clinical consultation is required. In a medical emergency, call 999.

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