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The original brand of mebeverine, an antispasmodic that relaxes the gut wall to ease IBS cramps, pain and bloating. For adults with IBS diagnosed by a doctor, after an online consultation with a GPhC-registered pharmacist prescriber.
For adults with IBS diagnosed by a doctor. Not for new or changed bowel symptoms at 60 or over, or in pregnancy or breastfeeding. Blood in your poo or weight loss needs your GP.
Order before 3pm — same-day dispatch (MON - FRI)
~5 min consultation
Secure & confidential · Reviewed by a UK prescriber
Suitable age
18 years and over
Max per order
Up to 3 months
Consultation
Yes, online consultation
Colofac is the original brand of mebeverine, made by Viatris. It’s an antispasmodic that relaxes the smooth muscle in the bowel wall, easing the cramping pain, bloating and urgency of IBS. Generic mebeverine 135mg contains the same medicine at the same strength.
For a twice-a-day option, there’s Colofac MR 200mg. Our guides to what mebeverine is used for and mebeverine vs Buscopan vs alverine explain how it compares. See all our IBS treatments.
| Active ingredient | Mebeverine hydrochloride 135mg |
| Brand | Colofac (Viatris) |
| Dose | 1 tablet three times a day, 20 minutes before meals |
| Prescription status | Prescription-only medicine, supplied after an online consultation |
| Suitable for | Adults 18+ with IBS diagnosed by a doctor |
| Price | 100 tablets £19.99 · 200 tablets £38.99 |
Who we can supply: adults 18 and over whose IBS has been diagnosed by a doctor. We don’t diagnose IBS online: if you haven’t been diagnosed, please see your GP. If you’re 60 or over, we can supply Colofac for IBS you’ve had for a while, but new or changed bowel symptoms need your GP.
See your GP first (don’t use this treatment) if you have: blood in your poo, or black poo; weight loss you can’t explain, or a lump in your tummy or back passage; a change in your bowel habit and you’re 60 or over; tummy swelling or bloating that won’t go away, especially if you’re 50 or over (women); a high temperature, vomiting, or severe pain that keeps getting worse; a family history of bowel or ovarian cancer, or of coeliac or inflammatory bowel disease, and new symptoms.
Our guide to IBS red flags explains why these matter.
This service isn’t suitable if you’re pregnant or breastfeeding. Please speak to your GP or midwife.
No common interactions with other medicines are known, but tell the prescriber everything you take.
Alcohol doesn’t interact with mebeverine, but it can trigger IBS symptoms.
If mebeverine doesn’t help, the prescriber can talk to you about other options, such as Buscopan IBS Relief, alverine or peppermint oil. Our guide to mebeverine vs Buscopan vs alverine compares them.
Colofac eases the cramping tummy pain, bloating and urgency of irritable bowel syndrome (IBS) by relaxing the muscle of the bowel wall.
Yes. Colofac is the brand; generic mebeverine contains the same medicine at the same strength.
Some people notice less cramping within a few days; others need a couple of weeks of regular use. If you’re not better after 2 weeks, see your GP.
Colofac 135mg is taken three times a day. Colofac MR 200mg releases the medicine slowly, so it’s taken twice a day. Take the one you’re prescribed.
They work differently, and some people respond better to one than the other. See mebeverine vs Buscopan vs alverine.
Many people take it through flares and stop between them. If you need it every day for months, have your IBS reviewed by your GP, especially if your symptoms change.
We don’t supply IBS medicines online in pregnancy or breastfeeding. Please speak to your GP or midwife.
Helpful articles and clinical guides related to this treatment category.
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Order before 3pm where offered
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Plain outer packaging