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Modified-release mebeverine, taken twice a day, for the cramps, pain and bloating of IBS. Colofac 135mg and generic mebeverine contain the same medicine.
Order before 3pm — same-day dispatch (MON - FRI)
~5 min consultation
Suitable age
18 years and over
Max per order
Up to 3 months
Consultation
Yes, online consultation
Colofac MR contains 200mg of mebeverine in a modified-release capsule, which releases the medicine slowly so you take it twice a day instead of three times. Mebeverine relaxes the muscle of the bowel wall, easing IBS cramps, pain and bloating.
| Active ingredient | Mebeverine hydrochloride 200mg, modified-release |
| Dose | 1 capsule twice a day, 20 minutes before meals |
| Legal category | Prescription-only medicine |
| Price | 60 capsules £19.99 · 120 capsules £29.99 |
Who we can supply: adults 18 and over whose IBS has been diagnosed by a doctor. We don’t diagnose IBS online: if you haven’t been diagnosed, please see your GP. If you’re 60 or over, we can supply Colofac MR for IBS you’ve had for a while, but new or changed bowel symptoms need your GP.
See your GP first (don’t use this treatment) if you have: blood in your poo, or black poo; weight loss you can’t explain, or a lump in your tummy or back passage; a change in your bowel habit and you’re 60 or over; tummy swelling or bloating that won’t go away, especially if you’re 50 or over (women); a high temperature, vomiting, or severe pain that keeps getting worse; a family history of bowel or ovarian cancer, or of coeliac or inflammatory bowel disease, and new symptoms.
Our guide to IBS red flags explains why these matter.
This service isn’t suitable if you’re pregnant or breastfeeding. Please speak to your GP or midwife.
No common interactions with other medicines are known, but tell the prescriber everything you take.
Alcohol doesn’t interact with mebeverine, but it can trigger IBS symptoms.
If mebeverine doesn’t help, the prescriber can talk to you about other options, such as Buscopan IBS Relief, alverine or peppermint oil. Our guide to mebeverine vs Buscopan vs alverine compares them.
Yes, it’s the same medicine: 1 tablet three times a day instead of 1 capsule twice a day. The prescriber will check it’s suitable, and you should let your GP know.
Yes. Mebeverine 200mg modified-release capsules are the generic of Colofac MR, and other brands, such as Bevispas, contain the same medicine.
Some people notice less cramping within a few days; others need a couple of weeks. If you’re not better after 2 weeks, see your GP.
No. Swallow them whole. Opening or chewing them releases all the medicine at once.
We don’t supply IBS medicines online in pregnancy or breastfeeding. Please speak to your GP or midwife.
Helpful articles and clinical guides related to this treatment category.
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Online review by a UK prescriber
Next-day delivery
Order before 3pm where offered
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Plain outer packaging