Kliofem Tablets is a continuous combined Hormone Replacement Therapy (HRT) that is taken every day without interruption. For use in postmenopausal women with at least 1 year since their last natural period.

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What is Kliofem?

Kliofem Tablets are a type of hormone replacement therapy (HRT) prescribed to relieve the symptoms of menopause in women.

Kilofem is sometimes used as a second-line option, it is beneficial in preventing osteoporosis in postmenopausal women.

Kliofem Tablets are a continuous form of HRT they contain a form of the normal female hormones oestrogen and progestogen called estradiol and norethisterone.

Kilofem is only to be used by post-menopausal women.

They should not be used by men or children.

How does Kliofem work?

During the time of menopause, the naturally produced levels of oestrogen in a women’s body decreases. This produces the symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness and irregular periods.

Kliofem Tablets contain estradiol, a naturally occurring form of oestrogen, to top up falling levels of the hormone and relieve symptoms of menopause.

The tablets also contain norethisterone, a synthetic form of progesterone.

Estradiol (oestrogen) stimulates the growth of the womb lining, unfortunately, this h has been linked to endometrial cancer, therefore it is essential to take it with norethisterone (progestogen) which opposes this effect.

Kliofem Tablets do not produce a monthly bleed, they are most suitable for women whose periods have completely stopped after menopause.

How to use Kliofem

Using Kilofem tablets

  • 28-day easy to use a calendar pack
  • One tablet should be taken every day.
  • There are no breaks
  • Try to take at the same time every day
  • The tablet should be swallowed whole ideally with a glass of water

Missed dose

If it’s less than 12 hours since you missed the dose, take the missed dose.

If it is more than 12 hours, you cannot make up for it, just take the next days dose at the regular time.

What dosages are available for Kliofem Tablets?

Each tablet contains 2mg estradiol (as estradiol hemihydrate) and 1mg norethisterone acetate.

These tablets come in a 28-day calendar pack.

Side effects & precautions


Kliofem Tablets could increase the levels of certain medicines in the blood, you should tell your doctor if you're taking any of these:

  • Ropinirole
  • Aminophylline
  • Selegiline
  • Tizanidine
  • theophylline.

Do not take these tablets if you are pregnant or breastfeeding.

Kliofem Tablets are not a contraceptive and will not prevent pregnancy.

Tell your doctor about any other medicines you are taking, including over-the-counter medicines, as these could affect how Kliofem Tablets work or increase your risk of side effects.


Side effects that have been commonly reported include:

  • Mood swings
  • Headache
  • Nausea and vomiting
  • Abdominal pain, bloating, flatulence, indigestion
  • Menstrual bleeding or spotting
  • Vaginal thrush
  • Increase in the size of uterine fibroids
  • Breast pain, tenderness or enlargement
  • Fluid retention, causing swelling (oedema).

If you are concerned about any of these or any other side effects, consult your doctor.

You should not take these tablets if you are allergic to any of their ingredients.

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