Differin 0.1%

Differin cream & gel contains the active ingredient Adapaline. Effective at reducing the number of acne, blackheads, and skin spots. It is also effective at decreasing swelling and inflammation in the skin.

Pack Size:
Product type:
Starting from
Order within
to receive your order by
After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.
Quick & Easy
No appointment or long waiting times
Discreet Packaging
Plain packaging with no medical stamps or marks
Confidential Service
Your information always remains private
Registered Pharmacy
Dispensed by our UK registered pharmacy

What is Differin?

Differin is used to treat acne present on the surface of the skin including blackheads and whiteheads.

It is a prescription-only medication, that contains an active ingredient called adapaline.

Adapaline is a retinoid which is derived from Vitamin A, and does not contain an antibiotic agent.

How does Differin work?

The active ingredient in Differin is called adapaline, which is a type of retinoid.

It works by regulating the turnover of skin cell growth, and makes sure the pores on the skin do not get clogged up. This faster skin turnover means that the skin can naturally exfoliate without causing blackheads and whiteheads from forming.

It also acts as an anti-inflammatory agent, reducing the redness and swelling on the skin, which is often seen with acne.

Differin v Epiduo

Differin v Tretinoin

Adapaline (the active ingredient in Differein) is a retinoid much similar to tretinoin, which is the active ingredient found in Treclin Gel.

Both are highly effective treatments for acne, and essentially have the same mode of action, and side effects.

If you do suffer from mild to moderate acne, you can use either products, however we suggest having a consultation with your own GP, doctor or dermatologist first to discuss the best treatment option for you.



Differin purge

A typical side effect of starting treatment with Differin, is a process known as purging.

This can last around 8-weeks, and involves the skin appearing worse as the spots become more noticeable. Although this may seem like the treatment is not working, the skin is actually getting better, as it begins its process of regulating and increasing the cell turnover rate.

This is a perfectly normal part of the treatment process, so do not be alarmed, as the skin will soon start showing an improvement.

Differin for acne scars

Is Differin safe to use whilst pregnant or breastfeeding?

Can you buy Differin over the counter in the UK?

How to use Differin

Use a mild face wash, to cleanse your face before applying Differin Gel. Apply a thin layer of Differn Gel once daily, even when you're not breaking out. Keep skin protected all the time with a hydrating sunscreen, and soothed at night with a soothing moisturizer. Retinoids are vitamin A derivatives that help reduce acne by increasing cell turnover. Differin contains tretinoin (Retin-A) as an active ingredient. Tretinoin is a synthetic form of Vitamin A. Tretinoin works by stimulating cell growth and reducing inflammation. This helps clear up acne.

How long does Differin take to work?

Treatment with Differin should continue for at least 8 weeks, and if the acne hasn't cleared by then, stop using it. If the acne clears up within 3 months, you can stop using Differin. However, if the acne doesn't clear up within 3 months, other treatments can be tried.

How long can you use Differin for?

Treatment with Differin should continue for at least 8 weeks, and if the acne hasn't cleared by then,  you should consider stopping it.

Differin can be used for many months or years if you derive benefit from it.

How effective is Differin?

Differin side effects

What is the difference between Differin cream and gel?

Product reviews for Differin

We’re here to help.

Our friendly team is available to help Monday to Friday 9:00am - 5:00pm.

If you need urgent assistance, do not use this service. Call 111, or in an emergency call 999.