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Domperidone is a prescription-only medicine used to relieve nausea and vomiting in adults and adolescents aged 12 and over who weigh at least 35kg. It works by blocking dopamine receptors involved in triggering the sensation of sickness, while also helping food move through the stomach more efficiently.
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Domperidone used to be available over the counter, but in 2014 the MHRA restricted it to prescription-only supply following a European safety review. The review found a small increased risk of serious heart rhythm problems, particularly in people over 60, those taking higher doses, or those on certain other medicines. Because of this, domperidone is now only supplied after a clinician has checked it's safe for you — including reviewing your medical history and any other medications you're taking.
Domperidone is typically taken 15 to 30 minutes before meals, and treatment is usually limited to the shortest time necessary — normally no more than one week — to relieve nausea and vomiting. It isn't suitable for everyone; people with certain heart conditions, severe liver problems, or those taking medicines that affect heart rhythm will usually need an alternative.
If domperidone may be right for you, our free online consultation lets one of our GPhC-registered pharmacist prescribers assess your suitability without needing a face-to-face GP appointment. If it's appropriate and safe, a prescription is issued and your medication is dispatched with discreet, next-day delivery available across the UK.
| Medicine type | Prokinetic antiemetic (dopamine antagonist) |
| Active ingredient | Domperidone 10mg |
| Effective within | 30–60 minutes |
| Recommended use | Nausea and vomiting; bloating and upper abdominal discomfort |
| Pack sizes | 30 tablets |
| Prescription status | Prescription Only Medicine (POM) |
| Maximum duration | 1 week (per MHRA guidance) |
| Side effects | Headache, dry mouth, raised prolactin; rarely QT prolongation |
| Generic available | Yes – generic domperidone 10mg tablets contain the same active ingredient as branded Motilium |
| Regulatory guidance | MHRA Drug Safety Update (2014); domperidone SmPC |
Nausea and vomiting are among the most common reasons people seek medical advice in the UK. They can be triggered by a wide range of causes — including gastroenteritis, migraines, certain medications, and post-operative recovery. Domperidone is one of the most commonly prescribed anti-sickness tablets in the UK and works specifically on the parts of the body responsible for triggering the sensation of nausea.
Domperidone is sometimes known by the brand name Motilium, though generic domperidone 10mg tablets contain the same active ingredient at the same strength and are fully licensed UK medicines regulated by the MHRA. If you’re looking to buy Motilium UK or generic domperidone online, our service provides a safe, prescription-based route with a free clinical consultation.
Domperidone 10mg tablets are used to relieve nausea and vomiting in adults and adolescents aged 12 and over who weigh at least 35kg. They may also help ease associated symptoms of bloating and upper abdominal discomfort. Domperidone is a prescription-only medicine — you cannot legally buy domperidone without a prescription. Our service makes it easy to obtain a valid domperidone prescription after a short online consultation.
Yes. Through Access Doctor's free online consultation, you can order domperidone without a face-to-face GP appointment. A UK-registered prescriber reviews your answers and, if domperidone is safe and appropriate for you, issues a prescription. This is the only legal way to buy domperidone online UK – we do not offer domperidone over the counter.
Domperidone is absorbed relatively quickly and typically begins to take effect within 30 to 60 minutes of taking a dose. For best results, it is recommended to take domperidone 15 to 30 minutes before meals.
In line with MHRA guidance, domperidone should be taken for the shortest time necessary — typically no longer than one week for the treatment of nausea and vomiting. If your symptoms continue beyond this period, please contact your GP or our clinical support team, as an alternative treatment or further investigation may be required.
Domperidone interacts with several medicines that are commonly prescribed in the UK. The most significant interactions involve CYP3A4 inhibitors (such as ketoconazole, clarithromycin, erythromycin, and certain antifungals) and QT-prolonging medicines (such as amiodarone, certain antipsychotics, and some antidepressants). Always tell your prescriber about all the medicines, supplements, and herbal remedies you are taking before starting domperidone medication.
Domperidone is considered safe for most adults and adolescents aged 12 and over (weighing at least 35kg) when used correctly — at the lowest effective dose for the shortest possible time. However, it is not suitable for patients with certain heart conditions, severe liver problems, a prolactinoma, or those taking specific interacting medicines. Our prescribers assess your full suitability as part of the free consultation.
In rare cases, high doses or prolonged use of domperidone can affect heart rhythm (QT prolongation). That’s why MHRA guidance limits use to one week and requires a prescription – another reason you should never attempt to buy domperidone from unverified sources.
Yes. Domperidone is a prescription-only medicine (POM) in the UK and cannot legally be sold without a valid prescription from a registered prescriber. Be cautious of any website offering domperidone for sale without an online consultation — this is not legal or safe practice in the UK.
The safety of domperidone during pregnancy has not been established and it is generally not recommended. Domperidone does pass into breast milk in small amounts; its use during breastfeeding is not routinely advised. If you are pregnant, breastfeeding, or planning a pregnancy, please speak to your GP or a registered healthcare professional before using domperidone tablets.
Complete Access Doctor's short, confidential online consultation — it takes around five minutes. If our UK-registered prescribers confirm domperidone is safe and appropriate for you, a prescription is issued and your medication dispensed by our GPhC-registered pharmacy (No. 9011198), often arriving next day in plain, discreet packaging. All orders include a free clinical consultation and access to our pharmacist support team. When you compare domperidone price or domperidone cost with other providers, remember that our service includes the online consultation, prescription, and ongoing support – with free repeat prescriptions and no hidden fees. Domperidone tablets uses summary: nausea, vomiting, bloating, upper abdominal discomfort. Always follow MHRA guidance and your prescriber’s advice.
Domperidone was moved to prescription-only status in 2014 after a safety review found a small increased risk of heart rhythm problems. A prescriber now needs to check your medical history and current medicines before it's supplied, to make sure it's safe for you.
Domperidone is considered safe for most adults and adolescents over 12 when taken at the recommended dose for a short period. However, it isn't suitable for everyone — particularly those with certain heart conditions or liver problems, or those taking specific interacting medicines. This is exactly why a consultation is required before it's prescribed.
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