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If you need urgent assistance, do not use this service. Call 111, or in an emergency call 999.
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An antispasmodic that relaxes the muscle of the gut wall to ease IBS cramps, pain and bloating. The generic of Colofac. For adults with IBS diagnosed by a doctor, after an online consultation with a GPhC-registered pharmacist prescriber.
For adults with IBS diagnosed by a doctor. Not for new or changed bowel symptoms at 60 or over, or in pregnancy or breastfeeding. Blood in your poo or weight loss needs your GP.
Order before 3pm — same-day dispatch (MON - FRI)
~5 min consultation
Secure & confidential · Reviewed by a UK prescriber
Suitable age
18 years and over
Max per order
Up to 3 months
Consultation
Yes, online consultation
Mebeverine is an antispasmodic. It relaxes the smooth muscle in the wall of the bowel, which eases the cramping pain, bloating and urgency of irritable bowel syndrome (IBS), without affecting normal gut movement. It’s the same medicine as Colofac 135mg, at a lower price. Our guide to what mebeverine is used for explains how it works and how long it takes.
It’s one of several IBS antispasmodics. Our guide to mebeverine vs Buscopan vs alverine compares them, and there’s a twice-a-day modified-release version (Colofac MR). See all our IBS treatments.
| Active ingredient | Mebeverine hydrochloride 135mg |
| Type | Antispasmodic |
| Dose | 1 tablet three times a day, 20 minutes before meals |
| Same medicine as | Colofac 135mg |
| Prescription status | Prescription-only medicine, supplied after an online consultation |
| Suitable for | Adults 18+ with IBS diagnosed by a doctor |
| Price | 100 tablets £19.99 · 200 tablets £29.99 |
Who we can supply: adults 18 and over whose IBS has been diagnosed by a doctor. We don’t diagnose IBS online: if you haven’t been diagnosed, please see your GP. If you’re 60 or over, we can supply mebeverine for IBS you’ve had for a while, but new or changed bowel symptoms need your GP.
See your GP first (don’t use this treatment) if you have: blood in your poo, or black poo; weight loss you can’t explain, or a lump in your tummy or back passage; a change in your bowel habit and you’re 60 or over; tummy swelling or bloating that won’t go away, especially if you’re 50 or over (women); a high temperature, vomiting, or severe pain that keeps getting worse; a family history of bowel or ovarian cancer, or of coeliac or inflammatory bowel disease, and new symptoms.
Our guide to IBS red flags explains why these matter.
This service isn’t suitable if you’re pregnant or breastfeeding. Please speak to your GP or midwife.
No common interactions with other medicines are known, but tell the prescriber everything you take.
Alcohol doesn’t interact with mebeverine, but it can trigger IBS symptoms.
If mebeverine doesn’t help, the prescriber can talk to you about other options, such as Buscopan IBS Relief, alverine or peppermint oil. Our guide to mebeverine vs Buscopan vs alverine compares them.
Small packs of mebeverine are pharmacy medicines for people whose IBS has already been diagnosed by a doctor. The 100 and 200 tablet packs are prescription-only. We supply them after an online consultation with a pharmacist prescriber.
The usual dose is 1 tablet three times a day, about 20 minutes before meals: 3 tablets in 24 hours. Don’t take more than prescribed. If that isn’t controlling your symptoms, see your GP rather than increasing the dose.
Some people notice less cramping within a few days; for others it takes a couple of weeks of regular use. If you’re not better after 2 weeks, see your GP. Our guide to what mebeverine is used for explains more.
Yes. Colofac 135mg is the original brand; generic mebeverine contains the same medicine at the same strength and costs less.
Neither is better for everyone. Mebeverine relaxes the gut muscle directly and has few side effects; Buscopan (hyoscine) blocks the nerve signals that cause spasm and can cause a dry mouth. Some people find one works better than the other. See mebeverine vs Buscopan vs alverine.
No. Mebeverine isn’t linked to weight loss. If you’re losing weight without trying, please see your GP, because unexplained weight loss isn’t a symptom of IBS. See IBS red flags.
Yes. It can be taken with fibre supplements, peppermint oil or loperamide if your prescriber agrees. Fybogel Mebeverine combines mebeverine with fibre in one sachet. Our guide to IBS subtypes explains which treatments suit IBS with diarrhoea, constipation or both.
We don’t supply IBS medicines online in pregnancy or breastfeeding. Please speak to your GP or midwife.
Helpful articles and clinical guides related to this treatment category.
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