Orlistat is the active ingredient in the popular weight loss medication Xenical.
The medication is available as the Branded form which is Xenical or the generic form which is Orlistat. The active ingredient and dosage are identical and will have the exact same effect.
Orlistat is used in combination with a balanced diet (reduced calories) and an exercise program to help people lose weight. Exercise and a balanced diet will help you maintain a healthy weight even when you stop taking your medication.
Orlistat is in a class of medications called lipase inhibitors. It works by preventing some of the fat in foods (approximately one-third) from being absorbed in the intestines. This unabsorbed fat is then removed from the body in the stool.
Orlistat does not affect the hormonal balance within your brain or have an impact on your hunger receptors.
Clinical studies have shown that Orlistat combined with diet and exercise, results in greater weight loss than diet alone. Orlistat, has been the subject in over 100 clinical studies. That makes Orlistat one of the most thoroughly studied weight loss drugs in the world, used by more than 50 million people.
Treatment Criteria for commencing on Orlistat:
- Orlistat should only be used by people who have a BMI of 25 or more (BMI stands for Body Mass Index, or an estimate of body fat)
- Patients should be over the age of 18 years
- Should be used along with a reduced-calorie/low-fat diet
- Orlistat is not suitable for women who are pregnant, or breastfeeding
- Orlistat is also not suitable for patients with food absorption difficulties or reduced bile flow
- It is particularly effective if you have previously found it difficult to lose weight with diet and exercise alone.
- Orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease
- Orlistat is also used after weight-loss to help people keep from gaining back that weight.
Orlistat comes as a capsule to take by mouth. The standard dose is one 120 mg capsule, and it is usually taken three times a day with each main meal that contains fat. Take Orlistat during a meal or up to 1 hour after a meal. If a meal is missed or does not have fat, you may skip your dose. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. To ensure your results are good and the weight loss is long lasting, it is important to combine Orlistat with exercise and a balanced diet containing no more than 30% fat.
If you miss a dose you can take it within an hour of your meal but do not take a double dose.
If you miss a meal or have a meal that has zero fat in it, you do not need to take your dose of Orlistat as it only works in the presence of fat in your diet.
How long is the treatment for?
If you have not had a reduction of at least 5% of body after 12 weeks, we recommend you stop using Orlistat.
Do not take Orlistat if:
- You have an allergy to Orlistat or any other medications.
- If you are on immunosuppressants (speak to your doctor first)
- If you have had an organ transplant
- If you have cholestasis (condition in which the flow of bile from the liver is blocked)
- You have malabsorption syndrome (problems absorbing food)
- You have an eating disorder such as anorexia nervosa or bulimia
- If you are pregnant, plan to become pregnant, or are breast-feeding
Orlistat may cause side effects. The most common side effect of orlistat is changes in bowel movement (BM) habits. This generally occurs during the first weeks of treatment; however, it may continue throughout your use of orlistat. Tell your doctor if any of these symptoms are severe or do not go away:
- Oily spotting on underwear or on clothing
- Gas with oily spotting
- Urgent need to have a bowel movement
- Loose stools
- Oily or fatty stools
- Increased number of bowel movements
- Difficulty controlling bowel movements
- Pain or discomfort in the rectum (bottom)
- Stomach pain
- Irregular menstrual periods
Serious side effect
- Difficulty breathing or swallowing
- Severe or continuous stomach pain
- Excessive tiredness or weakness
- Loss of appetite
- Pain in the upper right part of the stomach
- Yellowing of the skin or eyes
- Dark-coloured urine
- Light-coloured stools
Reporting of side effects
If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects listed on the attached leaflet. You can also report side effects directly via the internet at www.mhra.gov.uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine.
Safely obtaining the correct and most effective weight loss medications is made simple by AccessDoctor.
View the product section and choose a medication you think is suitable. One of our Access Doctors will review your request and suggest the most effective treatment choice for you. We take pride in providing a service that is a partnership between our doctors and you. We will provide regular advice and keep in touch to ensure that you are achieving your weight loss goals.
AccessDoctor is a UK based Pharmacy and Clinic, we are regulated by the Medicines & Healthcare Products Regulatory Agency (MHRA) and the General Pharmaceutical Council (GpHC). We only source and supply high quality genuine UK approved medicines.
Rest assured, our team consist of UK registered General Practitioners (GPs) with extensive knowledge and experience in weight loss management, If you have any queries you can contact our support team on 020 7538 4139 or email [email protected].