Premique Low Dose

Premique Low Dose is a hormone Replacement Therapy (HRT). It contains two types of female hormones, estrogen and progestogen. Premique Low Dose is a period-free HRT (an HRT product where you do not have a monthly bleed).

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What is Premique?

Premique tablets are a type of hormone replacement therapy (HRT).  They are used to treat menopause symptoms in women who are postmenopausal.

Premique contains two hormones.

  • conjugated oestrogens (0.3mg)
  • medroxyprogesterone acetate (1.5mg)

How to use Premique

How to use Premique

Premique tablets should be taken once a day, ideally at the same time every day.

If you miss a dose at your normal time, you can take it up to 12 hours afterwards. If it’s been longer than 12 hours then you should wait and only take the next dose at your regular time.

Side effects & precautions


Report any unexpected vaginal bleeding to your doctor

Examine your breasts regularly and let your doctor know about any changes

Go to your smear tests and mammograms

Attend regular treatment reviews with your GP

Make sure you give correct information on the following during your assessment for treatment:

  • Fibroids
  • Endometriosis or any womb problems
  • A close family member having breast cancer
  • High blood pressure
  • Liver problems
  • Diabetes
  • Gallbladder problems
  • Migraines
  • Systemic lupus erythematosus.
  • Epilepsy
  • Asthma
  • Otosclerosis
  • Hereditary angioedema


Stop using your Premique and contact a doctor immediately if you experience any of the following:

  • Jaundice
  • New headaches
  • High blood pressure
  • Breathing problems

For side effects associates with HRT, please read the section on HRT.

Read the attached patient information leaflet (PIL) for more information regarding this medication.

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Our friendly team is available to help Monday to Friday 9:00am - 5:00pm.

If you need urgent assistance, do not use this service. Call 111, or in an emergency call 999.